Amylase-producing tumors are mainly adenocarcinomas and, in rare insta
nces, multiple myelomas. We describe here a first case of amylase-prod
ucing Bence Jones type myeloma with pancreatitis-like symptoms and the
second in a Caucasian patient. The finding of salivary-type hyperamyl
asemia in a 72-year-old female with a possible pancreatitis made us su
spect the diagnosis. Amylase production was observed in bone marrow cu
ltures in which 96% of cellularity was composed of plasmablasts. Serum
amylase level decreased when chemotherapy was given.