The long-term prognosis after left tuberothalamic infarction was studi
ed in a selected group of 7 patients who had memory disturbances suffi
ciently severe to warrant neuropsychological consultation and rehabili
tation. The mean age of the patients was 46.7 +/- 5.6 years and the me
an follow-up time 22.3 +/- 15.0 months. At the acute stage 4 patients
had dysphasia, 1 hemiparesis, and 1 vertical gaze paresis. These impro
ved well. All 7 had memory disturbances, which remained the dominant d
isability. Four patients had severe behavioral symptoms (psychosis, de
pression, anxiety) at the acute stage. The most common residual behavi
oral symptoms were inactivity and depression. At the end of rehabilita
tion (mean 15.4 months) clear residual disturbances in verbal memory a
nd learning were still observed. These prevented return to work in all
but 1 case. No case of true dementia was found.