CLASSIFICATION OF HUMAN BRAIN PARTS USING PATTERN-RECOGNITION BASED ON INDUCTIVELY-COUPLED PLASMA-ATOMIC EMISSION-SPECTROSCOPY AND INSTRUMENTAL NEUTRON-ACTIVATION ANALYSIS
E. Andrasi et al., CLASSIFICATION OF HUMAN BRAIN PARTS USING PATTERN-RECOGNITION BASED ON INDUCTIVELY-COUPLED PLASMA-ATOMIC EMISSION-SPECTROSCOPY AND INSTRUMENTAL NEUTRON-ACTIVATION ANALYSIS, Chemometrics and intelligent laboratory systems, 22(1), 1994, pp. 107-114
This project aims at investigating possible trace element changes in h
istopathologically selected brain regions of patients with Alzheimer's
disease (six individuals, ten brain parts). Determinations were carri
ed out by inductively coupled plasma atomic emission spectrometry and
instrumental neutron activation analysis. The main (Na, K, Mg, Ca, Fe,
P, S) and trace (Al, B, Ba, Co, Cr, Cu, Mn, Ni, Pb, Sr and Zn) elemen
ts were investigated. Quality control was ensured by using Bovine Live
r standard reference materials from the National Bureau of Standards.
The results were graphically illustrated by means of cluster analysis
dendrograms where classification of the subjects is effected by placin
g them into homogeneous groups in a way that any relation between the
groups is revealed. Our preliminary results indicate a possible correl
ation of the brain Al and Zn concentrations (and the Sr, Ba, Cu conten
ts in some brain parts) with Alzheimer's disease.