LONG-TERM RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND THERAPEUTIC COMPARISON OF GLIPIZIDE AND GLYBURIDE - GLYCEMIC CONTROL AND INSULIN-SECRETION DURING 15 MONTHS
Ki. Birkeland et al., LONG-TERM RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND THERAPEUTIC COMPARISON OF GLIPIZIDE AND GLYBURIDE - GLYCEMIC CONTROL AND INSULIN-SECRETION DURING 15 MONTHS, Diabetes care, 17(1), 1994, pp. 45-49
Citations number
34
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
OBJECTIVE- To examine the long-term (15 months) effects on glycemic co
ntrol and insulin secretion of glipizide and glyburide treatment in pa
tients with noninsulin-dependent diabetes mellitus (NIDDM). RESEARCH D
ESIGN AND METHODS- Prospective, randomized, double-blind, placebo-cont
rolled study on 46 NIDDM patients comparing fasting levels and test-me
al responses of glucose and insulin during 15 months of follow-up. RES
ULTS- A comparable reduction in HbA1c levels by both agents versus pla
cebo was observed throughout the study period, but after a marked init
ial reduction in both sulfonylurea groups, all three groups showed gra
dually increasing HbA(1c), levels. However, both glipizide and glyburi
de achieved and maintained lowered postprandial glucose levels and inc
reased fasting and postprandial insulin levels compared with placebo.
CONCLUSIONS- Both glipizide and glyburide may achieve and maintain gly
cemic reduction and stimulation of insulin secretion during long-term
treatment. However, these agents do not prevent the gradual increase i
n overall glycemia that develops over time in NIDDM patients.