HIPPOCAMPAL EEG RESPONSES INDUCED BY CARBACHOL AND ATROPINE INFUSIONSINTO THE SEPTUM AND THE HIPPOCAMPUS IN THE URETHANE-ANESTHETIZED RAT

Citation
P. Monmaur et al., HIPPOCAMPAL EEG RESPONSES INDUCED BY CARBACHOL AND ATROPINE INFUSIONSINTO THE SEPTUM AND THE HIPPOCAMPUS IN THE URETHANE-ANESTHETIZED RAT, Brain research, 631(2), 1993, pp. 317-324
Citations number
36
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
00068993
Volume
631
Issue
2
Year of publication
1993
Pages
317 - 324
Database
ISI
SICI code
0006-8993(1993)631:2<317:HERIBC>2.0.ZU;2-7
Abstract
Infusion of 1 mu g of carbachol, a potent cholinergic agonist, into th e lateral septum of the urethane-anaesthetized rat systematically caus ed the induction of clear-cut hippocampal theta (theta). However, infu sion of an equivalent amount of the drug into the hippocampus, close t o the recording electrode, failed to induce theta in 50% of the animal s and produced a mixture of theta waves and desynchronized activity, r esulting in atypical EEG patterns, in the remaining subjects. Both car bachol EEG effects were blocked by intraseptal infusion of the antimus carinic agent, atropine. Our data demontrate that muscarinic receptors in the septum are predominent sites for cholinergic agonist-antagonis t action capable of generating or suppressing hippocampal theta in the rat. They also indicate that intraseptal cholinergic mechanisms play an important role in the initiation and generation of this rhythm.