A precocious line of Eimeria media was obtained by selection for early
development of oocysts in rabbits. The prepatent period was reduced f
rom 108 to 72 h. The precocious line was less pathogenic than the orig
inal strain, and its multiplication rate was lower. Rabbits given oocy
sts of the precocious line were totally immune to challenge with the o
riginal strain as assessed by change in weight gain but were partially
protected as assessed by oocyst output. Selection for precocious deve
lopment was accompanied by morphological changes in the sporulated ooc
ysts; each sporocyst contained only one large refractile body instead
of the two smaller bodies seen in the original strain.