The relevance of epicutaneous tests with fragrances is frequently disc
ussed. In the following, the reaction to perfumed substances under app
lication conditions is shown in seven volunteers with a positive epicu
taneous test to ''fragrance mix''. The fragrances used in those applic
ations are identical with those of the fragrance mix. Three leave-on p
roducts (deodorant spray, deodorant stick, and a skin care cream) and
one rinse-off product (shampoo) were tested. We found that an allergic
reaction did not constantly occur under each condition. Our volunteer
s reacted, depending an the product being used, quite differently. The
se results prove that a positive reaction to the fragrance mix does no
t inevidably mean a ban of perfumed products for the patients. Applica
tion with the cosmetics chosen by the patient should additionally be c
arried out.