INVOLVEMENT OF EP(3) SUBTYPE OF PROSTAGLANDIN-E RECEPTORS IN PGE(2)-INDUCED ENHANCEMENT OF THE BRADYKININ RESPONSE OF NOCICEPTORS

Authors
KUMAZAWA T MIZUMURA K KODA H
Citation
T. Kumazawa et al., INVOLVEMENT OF EP(3) SUBTYPE OF PROSTAGLANDIN-E RECEPTORS IN PGE(2)-INDUCED ENHANCEMENT OF THE BRADYKININ RESPONSE OF NOCICEPTORS, Brain research, 632(1-2), 1993, pp. 321-324
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
632
Issue
1-2
Year of publication
1993
Pages
321 - 324
Database
ISI
SICI code
0006-8993(1993)632:1-2<321:IOESOP>2.0.ZU;2-M
Abstract
Prostaglandin E(2) augments bradykinin-induced discharges of polymodal receptors as studied in vitro preparations. The antagonist and agonis ts for three subtypes of EP receptors were used to determine which sub type is involved in this phenomenon. The agonist for EP(3) (M&B28767) simulated the PGE(2)-induced effect but not for EP(2) (butaprost). The antagonist for EP(1) (AH6809) did not suppress the effect. These find ings indicate the involvement of the EP(3) receptor subtype in the eff ect.