Coccidioidomycosis is an infection originating in the San Joaquim Vall
ey of southern California, but now seen with increasing frequency thro
ughout southern California and the southwestern United States. Central
nervous system involvement is usually manifested as meningitis. The a
uthors present the case of a young man with pulmonary coccidioidomycos
is who developed a brain lesion that proved to be a coccidioidomycotic
abscess. With the increasing incidence of the disease, this manifesta
tion may be encountered more often and should therefore be included in
the differential diagnosis of any patient from an endemic area who pr
esents with a brain mass.