A giant cell tumor involving the vertex of the skull is described in a
3-year-old child with no history of head trauma. The mass was present
approximately 4 months prior to resection. Microscopically, the lesio
n consisted of highly cellular tissue composed of oval to spindle-shap
ed stromal cells admired with numerous multinucleated giant cells. Gia
nt cell tumor of the skull is a rare lesion, usually involving the sph
enoid or temporal bone in adults. The differential diagnosis is discus
sed with reference to the literature regarding giant cell lesions, esp
ecially of the cranium. The authors are unaware of previous reports of
a similar lesion in this location in such a young child.