PREVALENCE, INCIDENCE AND GEOGRAPHICAL-DISTRIBUTION OF TOXOPLASMA-GONDII ANTIBODIES IN PREGNANT-WOMEN IN DENMARK

The purpose of this study was to determine the prevalence and incidenc e of toxoplasmosis in pregnant women in Denmark, and to estimate the i ncidence of congenital toxoplasmosis. Consecutive serum samples from 5 ,402 women were analysed for specific IgG and IgM Toxoplasma gondii an tibodies by EIA. The prevalence of IgG antibodies was 27.4%. The seroc onversion rate was estimated to be 1.16% per year (SE = 0.0017) in all age groups, consistent with an incidence of acute toxoplasmosis in pr egnant women of 0.65 %. Specific IgM antibodies were present in sera f rom 29 women. Based on an assumed maternofetal transmission rate of 50 %, the incidence of congenital toxoplasmosis was estimated to be 0.33% . Based on these data it is predicted that about 410 pregnant women ar e infected with T. gondii every year in Denmark, and that about 200 ch ildren every year are infected in utero by T. gondii. There was no dif ference in the prevalence of antibodies in women from rural or urban a reas, or from different parts of Denmark.