THE INFLUENCE OF RADIOTHERAPY AND CHEMOTHERAPY ON REGENERATION AT ARTERIAL MICROANASTOMOSES - AN EXPERIMENTAL AND CLINICAL-STUDY

Authors
SIDOROV VB MINACHENKO VK REKHTER MD PSHENISNOV KP MIRONOV AA BAUMAN OA
Citation
Vb. Sidorov et al., THE INFLUENCE OF RADIOTHERAPY AND CHEMOTHERAPY ON REGENERATION AT ARTERIAL MICROANASTOMOSES - AN EXPERIMENTAL AND CLINICAL-STUDY, Annals of plastic surgery, 32(1), 1994, pp. 45-51
Citations number
8
Categorie Soggetti
Surgery
Journal title
Annals of plastic surgery → ACNP
ISSN journal
01487043
Volume
32
Issue
1
Year of publication
1994
Pages
45 - 51
Database
ISI
SICI code
0148-7043(1994)32:1<45:TIORAC>2.0.ZU;2-C
Abstract
The regeneration of anastomosed aortas after radiotherapy and chemothe rapy was studied by light, scanning, and transmission electron microsc opy in a rat model. At the ultrastructural level, it was observed that sublethal doses of these methods of cancer treatment did not severely block endothelial proliferation in the region of the microanastomosis . Based on the experimental results, myocutaneous free flap transfers were completed in patients with malignant tumors who had been undergoi ng radiotherapy and chemotherapy to cover defects resulting from their excision.