EXPERIENCE OF PREPARING INACTIVATED VACCI NE AGAINST LASSA FEVER

A single and double immunization of Papio hamadryas monkeys with an in activated concentrated purified adsorbed preparation of Lassa virus in doses of 0.5-1.0 and 1.1-2.1 mg by protein, respectively, protected t he animals against the development of the disease and occurrence of vi remia after an intramuscular challenge with 0.4 PFU dose. Upon aerogen ic infection of monkeys protection of 50 % of the animals was achieved by a single immunization with the inactivated preparation in a dose 1 .1 mg by protein.