EFFICACY OF OXYGEN DELIVERY TO TISSUES UN DER COMPLETE REPLACEMENT OFBLOOD FOR BOVINE POLYHEMOGLOBIN

The study has been performed to test the hypothesis on feasibility of omitting pyridoxylation in production of bovine polyhemoglobin as comp ared to polyhemoglobin from human red cells. The model of a complete r eplacement of rabbit blood for polyglucin (Het almost-equal-to 2%) was used to compare efficacy characteristics for O2 delivery to tissues u pon introduction of bovine polyhemoglobin against rabbit red cells. Im mediately after the replacement, O2 release efficacy and that of circu lation were identical, whereas 30 and 60 min after it, developing deco mpensation of hemodynamics indicated inability of bovine heterohemoglo bin, unlike own red cells, to increase A-B difference by oxygen, proba bly due to metform rise.