THE EFFECT OF BASIC PLASMIC POLYPEPTIDES ON COAGULATION AND FIBRINOLYSIS

An original method was used to isolate polypeptides from citrate plate let-free plasma of healthy subjects. These polypeptides were able to p rolong recalcification, kaolin, kaolin-kephalin and prothrombin plasma time, sharply reduce thrombine time of standard and heparinized plasm a, to inhibit fibrin self-building and stimulate fibrinolytic activity of blood. An antiheparin effect of polypeptides in adequate doses is similar to that of protamin sulfate. Polypeptide antiheparin plasma fa ctor has molecular mass about 2000 D, its chromatographic profile coin cides with that of protamin sulfate.