DISTRIBUTION OF IMMUNOGENETIC MARKERS OF RED-CELL SYSTEMS IN CORONARYHEART-DISEASE

Distribution of 24 phenotypes of 6 red cell systems (ABO, Rh - Hr, MNS s, Duffy, Kell-Chellano, Kidd) has been studied for the first time in 275 coronary patients of Armenian nationality. Antigens ABO and MN wer e determined by hemagglutination, antigen Rho(D) by conglutination, an tigens C, c, E, e, Fy(a), Fy(b) Jk(a), Jk(b), K and k by indirect Coom bs reaction. Out of the 6 systems, only heterozygous phenotype Cc and homozygous phenotype Jk (a-b+) were positively associated with coronar y heart disease. The carriers of the former,had a risk of CHD 2.2-time s that for patients carrying CC and Jk (a+b+), while the carriers of t he latter had this risk increased 5-fold. Simultaneous identification of Kidd system phenotypes and Rh-Hr (Jk(b) (a-b+) and CC in the same p atient may be considered as a genetic CHD marker in Armenian populatio n. The above fact needs special attention in early preclinical diagnos is and prevention of CHD.