INTERPRETIVE CRITERIA FOR CEFODIZIME IN-VITRO SUSCEPTIBILITY TESTS WITH NEISSERIA-GONORRHOEAE

Cefodizime was tested against 100 strains of Neisseria gonorrhoeae wit h varying susceptibility patterns to penicillin. Agar-dilution minimum inhibitory concentrations (MIC) and disk diffusion susceptibility tes ting were performed in triplicate for each strain according to Nationa l Committee for Clinical Laboratory Standards (NCCLS) guidelines to es tablish susceptibility interpretive criteria for this beta-lactamase-s table cephalosporin. Cefodizime was very active against these strains of N. gonorrhoeae, with a MIC(50) of Only 0.008 mu g/ml. Because no re sistant strains were documented, a single susceptible criterion of les s than or equal to 0.05 mu g/ml (greater than or equal to 31 mm) was p roposed to predict clinical success offer a single intramuscular (i.m. ) dose.