T. Hennig et al., DETECTION OF BRAIN ACTIVATION USING OXYGENATION SENSITIVE FUNCTIONAL SPECTROSCOPY, Magnetic resonance in medicine, 31(1), 1994, pp. 85-90
A nonwater-suppressed localized spectroscopy experiment using the PRES
S-sequence has been used to study the signal changes of the water reso
nance during cortical activation. Significant effects with an effect-t
o-noise ratio up to 50:1 for a single shot experiment have been observ
ed upon photic stimulation. The exceedingly high signal-to-noise ratio
of the experiment was used to demonstrate signal changes as low as 0.
1% after electrical stimulation of the median nerve.