ACOUSTIC RHINOMETRY COMPARED WITH POSTERIOR RHINOMANOMETRY IN THE MEASUREMENT OF HISTAMINE-INDUCED AND BRADYKININ-INDUCED CHANGES IN NASAL AIRWAY PATENCY

1 Acoustic rhinometry is a relatively new method for objectively asses sing nasal airway patency. In this paper we compare acoustic rhinometr y with active posterior rhinomanometry. 2 Twenty normal healthy volunt eers underwent nasal challenge with either histamine or bradykinin, 10 0 mug to 1000 mug, and responses were assessed by acoustic rhinometry. A further 20 subjects received identical nasal challenges and respons es were assessed by active posterior rhinomanometry. 3 On a subsequent occasion, the subjects challenged previously with histamine, were giv en the selective H-1-receptor antagonist, cetirizine, 10 mg orally, 3 h before repeat nasal challenge with histamine, 100-1000 mug. Again, r esponses were assessed by active posterior rhinomanometry and acoustic rhinometry. 4 The acoustic reflection measurements and the nasal airw ay resistance measurements showed comparable, significant dose-related changes in nasal patency to both histamine and bradykinin. Pretreatme nt with cetirizine blocked the histamine-induced change in nasal paten cy as measured by both methods. 5 We conclude that acoustic rhinometry has a number of advantages over posterior rhinomanometry. It is quick to perform, requires minimal subject co-operation and gives a reliabl e objective, measurement of dose-related changes in nasal airway paten cy before and after pharmacological treatment.