This case-referent study evaluated cancer risks among farmers in centr
al Italy. Cancer cases (N = 1674, 17 sites) were selected from all dec
eased men aged 35-80 years; a random sample of 480 decedents formed th
e reference series. Farmers had a decreased risk of lung and bladder c
ancer and melanoma and nonsignificant excess risks for stomach, rectal
, kidney, and nonmelanoma skin cancer. Stomach and kidney cancer were
significantly increased among the farmers with > 10 years' experience,
and stomach, rectal, and pancreatic cancer were increased among licen
sed pesticide users with > 10 years' experience. Possible relationship
s emerged between specific crops and cancer: fruit and colon and bladd
er cancer, wheat and prostate cancer, olives and kidney cancer, and po
tato and kidney cancer. The results regarding stomach, pancreatic, lun
g, bladder, and prostate cancer and melanoma congrue with earlier resu
lts. The kidney cancer excess, the association of colon and bladder ca
ncer with orchard farming, and the excess of rectal cancer among licen
sed farmers are new and unexpected findings.