The ability to predict amputation following combined orthopedic, vascu
lar and soft tissue trauma to an extremity could eliminate prolonged a
ttempts at salvage of a doomed Limb. We reviewed our experience with 4
8 mangled lower extremities in 46 patients. Twenty-one penetrating wou
nds and 25 blunt injuries occurred in 37 men and nine women ranging in
age from 3 to 59 years. Severity of injuries to muscle, skin, and maj
or nerves were strongly interrelated (r = 0.49 to 0.74, P < 0.001), bu
t there were no correlations between injuries to these tissues and sev
erity of bone injury (r < 0.19, P > 0.20). Twenty-four limbs were salv
aged, and 24 were amputated. Increased severity of soft tissue injury
was associated with a greater probability of limb loss (P < 0.001), bu
t limb salvage or amputation could not be predicted accurately by any
variable or group of variables such as age, mechanism of injury, Injur
y Severity Score, presence of shock, level of injury, venous injury or
repair, sequence of repair (vascular vs skeletal), time of fasciotomy
, arteriography, blood requirement, or duration of ischemia. Amputatio
n was best predicted by severity of injury to the sciatic or tibial ne
rves (P < 0.001), and by failure of arterial repair (P < 0.01). Severe
extremity injuries require a coordinated approach and decisions regar
ding amputation require careful judgement. These decisions cannot alwa
ys be made at the time of presentation or during the initial operation
. If after revascularization and skeletal stabilization the extremity
is clearly nonviable or remains insensate, then delayed amputation can
be performed under more controlled circumstances.