Jm. Oriordan et al., LOCALIZED, LATE-ONSET, HIGH-GRADE LYMPHOMA FOLLOWING BONE-MARROW TRANSPLANTATION - RESPONSE TO COMBINATION CHEMOTHERAPY, British Journal of Haematology, 86(1), 1994, pp. 183-186
Non-Hodgkin's lymphoma is the commonest secondary cancer following bon
e marrow transplantation (BMT). We report the case of a 42-year-old ma
n who developed a laryngeal high-grade B-cell lymphoma 5 years followi
ng a matched T depleted BMT for CML. Polymerase chain reaction (PCR) a
nalysis using the microsatellite marker Cyp 19 demonstrated the donor
origin of involved tissue. Epstein-Barr virus (EBV) genomic sequences
were identified by PCR. Although EBV related B-cell lymphoproliferativ
e disorders (BLPD) post BMT are difficult to treat, there was a comple
te remission in this patient following three courses of chemotherapy (
CHOP) administered with G-CSF. This case of late-onset BLPD appears cl
inically distinct from the well-defined, aggressive early post-transpl
ant BLPD.