SIGNIFICANCE OF EPIDERMAL GROWTH-FACTOR RECEPTOR EXPRESSION IN PRIMARY HUMAN ENDOMETRIAL CANCER

Radioreceptorial assessment of EGFR expression was prospectively perfo rmed on 60 primary human endometrial tumors. Of these, 26 were EGFR-po sitive while 13 expressed high EGFR levels. High EGFR levels correlate d well with poor histopathological grading. No correlation with histop athological type, stage, myometrial invasion, lymph-node involvement o r steroid hormone receptor status was observed. Disease-free survival rate was significantly shorter in the cases with high than in the case s with low EGFR levels. These results suggest a potential role of EGFR expression assessment in prognostic characterization of endometrial c ancer patients. (C) 1994 Wiley-Liss, Inc.