DETERMINATION OF THE GLOMERULAR-FILTRATIO N RATE (GFR) IN DOG BY AN IODINE CONTRAST-MEDIUM WITH THE RENALYZER-PRX-90

Determination of the glomerular filtration rate (GFR) is an important functional parameter for the diagnosis of nephropathies. The present s tudy describes a simple procedure to measure the GFR by an iodine cont rast medium clearance with the Renalyzer-PRX 90. Based on investigatio n of 35 dogs without nephropathies a reference value for the GFR of 3, 0 to 6,5 ml/min/kg BW (xBAR = 4,4, +/- 2 s = 1,8) was determined. In 3 2 patients suffering from uremia the GFR was decreased (0,1-2,6 ml/min /kg BW). To confirm the nephropathia in 26 of these cases a sodium dod ecyl sulfate-polyacrylamide-gradient gel electrophoresis (SDS - PAGE) with Phast System and in 11 cases histological examination of the kidn eys was performed. The Renalyzer-PRX 90 allows a reliable measurement of the glomerular filtration capacity in the dog and is an important s upplement to the diagnostic spectrum in nephropathies. The procedure c auses also to the ill dog little discomfort and gives a reliable resul t within a few hours.