STABILITY OF AQUEOUS CARBOPLATIN SOLUTIONS UNDER ILLUMINATION

The stability of carboplatin in aqueous solutions at different experim ental conditions was studied. It was observed that the degradation rat e of carboplatin under illumination increases notably with respect to the rate obtained in the dark. The time course of carboplatin in solut ion follows a first-order kinetics with rate constants that depend on the incident light intensity and little with temperature. The quantum yield of the carboplatin degradation lies between 0.05 and 0.2 dependi ng on the experimental conditions. From the results obtained in the pr esent work it is concluded that carboplatin is degraded under illumina tion by means of a photoaquation process.