W. Riegel et Wh. Horl, POTENTIAL NEPHROTOXICITY OF 2ND GENERATIO N CEPHALOSPORINS - CEFUROXIME VERSUS CEFOTIAM, Infection, 21, 1993, pp. 190000014-190000016
Forty-one hospitalized patients were randomized to be treated with cef
uroxime (4.05 g/die) or cefotiam (5.30 g/die). Several patients receiv
ed additionally furosemide (0.5 mg/kg body weight) intravenously. Seru
m creatinine and creatinine clearance did not show significant differe
nces during versus after treatment in any of the groups. Cefotiam or c
efotiam/furosemide treated patients displayed higher proteinuria and h
igher urinary excretion of lysosomal enzymes (leucine aminopeptidase)
than patients treated with cefuroxime or cefuroxime/furosemide. Our da
ta indicate higher tubulotoxicity of cefotiam compared to cefuroxime.