SYNTHESIS OF HIGHLY ENANTIOMERICALLY ENRICHED CYCLIC AMINES BY THE CATALYTIC ASYMMETRIC HYDROGENATION OF CYCLIC IMINES

Authors
WILLOUGHBY CA BUCHWALD SL
Citation
Ca. Willoughby et Sl. Buchwald, SYNTHESIS OF HIGHLY ENANTIOMERICALLY ENRICHED CYCLIC AMINES BY THE CATALYTIC ASYMMETRIC HYDROGENATION OF CYCLIC IMINES, Journal of organic chemistry, 58(27), 1993, pp. 7627-7629
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
58
Issue
27
Year of publication
1993
Pages
7627 - 7629
Database
ISI
SICI code
0022-3263(1993)58:27<7627:SOHEEC>2.0.ZU;2-F
Abstract
The asymmetric hydrogenation of cyclic ketimines with a chiral titanoc ene catalyst affords amines with excellent enantioselectivity under a variety of conditions. The reaction is general for cyclic imines of ri ng size 5-7 and exhibits a high degree of functional group compatibili ty.