PREPARATION, CHARACTERIZATION, AND PHARMACEUTICAL APPLICATION OF LINEAR DEXTRIN .3. DRUG-RELEASE FROM FATTY SUPPOSITORY BASES CONTAINING AMYLODEXTRIN

Drug release from fatty suppository bases containing a solid dispersio n of diazepam with amylodextrin or a complex of prednisolone with amyl odextrin was analyzed in a flow-through model. Being present as a susp ension in the fatty base, particles of complex or solid dispersion are transported to the lipid-water interface by sedimentation. After ente ring the aqueous phase they partially dissolve. The suppositories show ed increased drug release compared with the corresponding suppositorie s containing drug only. Because of the partial solubility of amylodext rin, drug release was lower than the release from drug-cyclodextrin co mplexes. Use of the soluble fraction of amylodextrin for both the soli d dispersion and the complex further enhanced drug release, but it was still below that of drug-cyclodextrin complexes.