BIOAVAILABILITY OF FLUMEQUINE AFTER SEMISIMULTANEOUS ADMINISTRATION TO VEAL CALVES

The absolute bioavailability of flumequine after semisimultaneous intr amuscular administration as a water-based suspension to veal calves wa s 92 +/- 14%. The semisimultaneous experimental design Provided a reli able determination of absorption rate and demonstrated flip-flop pharm acokinetics. No period or sequence effects were detected. Calculated e limination rate, clearance, and volume of distribution after intraveno us administration were comparable to values obtained from traditional design studies. The semisimultaneous experimental design proved to be valuable for the assessment of bioavailability and pharmacokinetics of drugs in food-producing animals while preventing violation of basic c learance assumptions.