BIODISTRIBUTION OF MIXED FLUOROCARBON HYDROCARBON DOWEL MOLECULES USED AS STABILIZERS OF FLUOROCARBON EMULSIONS - A QUANTITATIVE STUDY BY FLUORINE NUCLEAR-MAGNETIC-RESONANCE (NMR)
L. Zarif et al., BIODISTRIBUTION OF MIXED FLUOROCARBON HYDROCARBON DOWEL MOLECULES USED AS STABILIZERS OF FLUOROCARBON EMULSIONS - A QUANTITATIVE STUDY BY FLUORINE NUCLEAR-MAGNETIC-RESONANCE (NMR), Pharmaceutical research, 11(1), 1994, pp. 122-127
F-19 NMR spectroscopy was used to determine quantitatively the organ d
istribution and organ retention time in rats of the mixed fluorocarbon
-hydrocarbon dowel molecule C6F13CH = CHC10H21 (F6H10E), which stabili
zes highly concentrated injectable fluorocarbon emulsions destined for
in vivo oxygen transport and delivery. The only fluorine resonances d
etected in the F-19 NMR spectra of the organs analyzed were those of t
he F6H10E dowel itself, indicating that metabolites, if present, have
very low concentrations (<10(-4) M, limit of our assay). The F6H10E co
ntent in the liver peaked 1 day after administration (7 days for the s
pleen). At a dose of 3.6 g/kg body weight, the half-life of F6H10E in
the liver was 25 +/- 5 days.