IN-VITRO ACTIVITY OF 3 CARBAPENEM ANTIBIOTICS - COMPARATIVE-STUDIES WITH BIAPENEM (L-627), IMIPENEM, AND MEROPENEM AGAINST AEROBIC PATHOGENS ISOLATED WORLDWIDE
Dj. Hoban et al., IN-VITRO ACTIVITY OF 3 CARBAPENEM ANTIBIOTICS - COMPARATIVE-STUDIES WITH BIAPENEM (L-627), IMIPENEM, AND MEROPENEM AGAINST AEROBIC PATHOGENS ISOLATED WORLDWIDE, Diagnostic microbiology and infectious disease, 17(4), 1993, pp. 299-305
The in vitro activity of biapenem (formerly L-627 or LJC10, 627), a ne
w carbapenem, was compared with that of imipenem and meropenem against
>6000 clinically significant pathogens isolated in six countries worl
dwide. Biapenem was active against members of the family Enterobacteri
aceae with a 90% minimum inhibitory concentration (MIC(90)) ranging fr
om less than or equal to 0.06 to 2 mu g/ml. Only Serratia spp. and Pro
videncia spp. were less susceptible (MIC(90), 8 mu g/ml). Pseudomonas
aeruginosa and Xanthomonas maltophilia displayed an MIC(90) of greater
than or equal to 8 mu g/ml biapenem/ml whereas Acinetobacter spp. wer
e susceptible at less than or equal to 1 mu g/ml. Oxacillin-resistant
staphylococci were resistant to biapenem at >8 mu g/ml whereas oxacill
in-sensitive staphylococci were susceptible at less than or equal to 1
mu g/ml. Biapenem, imipenem, and meropenem displayed poor activity ag
ainst Ent. faecium (MIC(90), greater than or equal to 8 mu g/ml), and
only imipenem displayed slightly better activity against Ent. faecalis
(MIC(90), 4 mu g/ml). The rank order of activity against groups of is
olates was Enterobacteriaceae (meropenem>biapenem greater than or equa
l to imipenem), Ps. aeruginosa (biapenem=meropenem=imipenem), oxacilli
n-sensitive staphylococci (imipenem greater than or equal to biapenem=
merepenem), oxacillin-resistant staphylococci (biapenem=meropenem=imip
enem), and Enterococcus spp. (biapenem=meropenem=imipenem). These in v
itro results suggest that further developmental work on biapenem is wa
rranted.