IN-VITRO COMPARISON OF E4868, A NEW TRIFLUOROQUINOLONE, WITH CIPROFLOXACIN AND TEMAFLOXACIN TESTED AGAINST 5192 RECENT CLINICAL ISOLATES FROM 5 MEDICAL-CENTERS

The in vitro activity of E4868 was compared with that of ciprofloxacin and temafloxacin in a multicenter study. More than 90% of Enterobacte riaceae and 82% of the 651 isolates of Pseudomonas aeruginosa, as well as >95% of the oxacillin-susceptible staphylococci, 100% of the beta- hemolytic streptococci, and 76% of the enterococcal isolates were susc eptible to E4868 (minimum inhibitory concentrations, less than or equa l to 2 mu g/ml). E4868 was generally equivalent or slightly less activ e than ciprofloxacin against the Enterobacteriaceae and Pseudomonas an d more active against straphylococci and beta-hemolytic streptococci. The activity of E4868 was generally equivalent to or slightly greater than that of temafloxacin against all major groups of organisms.