PREDICTION OF BACTERIAL SUSCEPTIBILITY TO CEFPODOXIME BY USING THE CEFTRIAXONE MINIMUM INHIBITORY CONCENTRATION RESULT

The cross-resistance or cross-susceptibility of cefpodoxime and ceftri axone for 3700 strains of Enterobacteriaceae, oxacillin-susceptible st aphylococci, Streptococcus spp., Haemophilus influenzae, Moraxella cat arrhalis, and Neisseria gonorrhoeae was evaluated. With the exception of tests with Enterobacter spp. and Morganella morganii, the ceftriaxo ne minimum inhibitory concentration (MIC) result interpretive criteria predicted bacterial susceptibility (or resistance) to cefpodoxime wit h an acceptable rate of serious interpretive errors (1.5%) and an abso lute categorical agreement >92%. By using cefpodoxime interpretive cri teria for ceftriaxone MICs, the interpretive errors for testing enteri c bacilli were reduced from 2.2% to 1.5%.