LIQUID-CHROMATOGRAPHY AND CAPILLARY ELECTROPHORESIS ANALYSIS OF POLYANIONIC QUINOBENE

Quinobene is the tetrasodium salt of an organic tetrasulphonic acid. I ts unusual solubility characteristics makes the development of LC anal ysis difficult. However, a specific, precise and accurate LC assay was eventually achieved for quinobene. The assay required gradient elutio n and was not efficient for quinobene with respect to plate number.:As an alternative, a capillary electrophoresis (CE) assay was also devel oped for quinobene. The CE assay was comparable to the LC assay in pre cision and accuracy. It was unaffected by the unusual solubility chara cteristics of quinobene and was more specific, efficient and rugged th an the LC assay.