Rb. Taylor et Rg. Reid, ANALYSIS OF BASIC ANTIMALARIAL-DRUGS BY CZE AND MEKC .1. CRITICAL FACTORS AFFECTING SEPARATION, Journal of pharmaceutical and biomedical analysis, 11(11-12), 1993, pp. 1289-1294
The separations of 11 antimalarial drugs and metabolites are shown by
CZE at low pH and by MEKC at high pH. CZE is shown to be superior to M
EKC in resolution capability for these compounds under the conditions
examined. Both are shown to provide different selectivities to those o
btained by ion-pair reversed-phase HPLC. The effect of sample injectio
n solvent is examined in CZE and it is shown that field-amplified samp
le injection is effective for these compounds. In addition, it is show
n that injection of sample in an organic solvent such as methanol augm
ents the stacking of analytes resulting in lower detection limits. The
limit of detection of some antimalarials in a urine matrix is reporte
d.