Ca. Verburgh et al., INTERLEUKIN-8 (IL-8) IN SYNOVIAL-FLUID OF RHEUMATOID AND NONRHEUMATOID JOINT EFFUSIONS, Clinical rheumatology, 12(4), 1993, pp. 494-499
IL-8 was measured in knee joint synovial fluid of 60 patients with rhe
umatoid arthritis, 8 with gout, 6 with osteoarthritis and 4 with menis
cus lesions. IL-8 could be demonstrated in most SF samples. The highes
t levels were observed in rheumatoid joint effusions, yet mean levels
were not significantly different between the different subgroups (mean
+/- SE; RA 1537 +/- 3049 pg/ml, gout 570 +/- 952 pg/ml, OA/ML 178 +/-
188 pg/ml). In RA patients, IL-8 levels could not be related to vario
us serological, clinical or radiological parameters. However, a correl
ation was observed between SF levels of IL-8 with those of lactate, LD
H, beta 2-microglobulin and glucose. These observations suggest that n
ext to the laboratory parameters IL-8 will be a parameter of the activ
ity of the local inflammatory process. The results also demonstrate th
at IL-8 is not a disease-specific marker of joint inflammation.