MURINE HYBRIDOMAS SECRETING MONOCLONAL-ANTIBODIES REACTING WITH MLS(A) ANTIGENS

Authors
DEGIORGI L DEMATOS C ELLIS BA MATOSSIANROGERS A
Citation
L. Degiorgi et al., MURINE HYBRIDOMAS SECRETING MONOCLONAL-ANTIBODIES REACTING WITH MLS(A) ANTIGENS, Experimental and clinical immunogenetics, 10(4), 1993, pp. 219-223
Citations number
23
Categorie Soggetti
Genetics & Heredity",Immunology,Biology
Journal title
Experimental and clinical immunogenetics → ACNP
ISSN journal
02549670
Volume
10
Issue
4
Year of publication
1993
Pages
219 - 223
Database
ISI
SICI code
0254-9670(1993)10:4<219:MHSMRW>2.0.ZU;2-1
Abstract
Murine monoclonal antibodies have been developed from spleens of AKR m ice hyperimmunised with the monoclonal antibody against TCR-Vbeta6. Tw o new monoclonal antibodies called AL-12-3 and AL-32-7 were able to sp ecifically block Mls(a)-induced but not MHC-induced mixed lymphocyte r esponses in a dose-dependent manner. Both antibodies are mouse IgG3 la mbda chain isotype and bind to Mls(a)-bearing lymphocytes from differe nt strains of mice. The availability of such antibodies may well facil itate future research aimed at immunochemical and molecular characteri zation of Mls de terminants.