M. Bryjak et al., ENANTIOSELECTIVE TRANSPORT OF AMINO-ACID THROUGH SUPPORTED CHIRAL LIQUID MEMBRANES, Journal of membrane science, 85(3), 1993, pp. 221-228
Two chiral alcohols, nopol and (2S)-(-)-methyl-1-butanol, immobilized
in the pores of a polyethylene film were used for the enantioselective
transport of amino acid hydrochloride. The degree of stereoselectivit
y of the permeation process varied from 0.39 to 1.52 depending on both
the type of the chiral membrane phase and the properties of the amino
acid. The evaluation of the membrane ability to separate stereoisomer
s was performed by the step-by-step analysis by considering the effect
of amino acids' hydrophobicity, polarity and degree of chirality. For
the purpose of this paper, the chirality measure was introduced. It w
as demonstrated that the enantioselectivity was affected mainly by the
degree of chirality, and that the nopol membrane was the most efficie
nt one.