DESPITE ITS HIGH REPRESENTATION IN EXTRACHROMOSOMAL CIRCULAR DNAS FROM DROSOPHILA EMBRYOS, THE DODECASATELLITE DOES NOT ALLOW AUTONOMOUS REPLICATION IN CULTURED-CELLS

Authors
RENAULT S DEGROOTE F PICARD G
Citation
S. Renault et al., DESPITE ITS HIGH REPRESENTATION IN EXTRACHROMOSOMAL CIRCULAR DNAS FROM DROSOPHILA EMBRYOS, THE DODECASATELLITE DOES NOT ALLOW AUTONOMOUS REPLICATION IN CULTURED-CELLS, Biology of the cell, 79(1), 1993, pp. 51-54
Citations number
24
Categorie Soggetti
Cytology & Histology
Journal title
Biology of the cell → ACNP
ISSN journal
02484900
Volume
79
Issue
1
Year of publication
1993
Pages
51 - 54
Database
ISI
SICI code
0248-4900(1993)79:1<51:DIHRIE>2.0.ZU;2-N
Abstract
The dodecasatellite is a 11/12 bp tandemly repeated sequence which is overrepresented, with regard to its genomic representation, in extrach romosomal circular DNAs from D melanogaster embryos. Here we Show that a bacterial plasmid carrying a cluster of dodecasatellite is not able to replicate efficiently in cultured cells. This observation does not support the hypothesis that the over-representation results from an a utonomous replication of dodecasatellite circular DNA molecules.