EFFECT OF MILK ON ABSORPTION OF NORFLOXACIN IN HEALTHY-VOLUNTEERS

The authors studied the effect of milk on the bioavailability of norfl oxacin in six healthy male volunteers in a randomized crossover trial. After an overnight fast, 200 mg of norfloxacin was given with 200 mt of water or milk. Area under the curve (AUC) of norfloxacin with milk was significantly (P < 0.01) smaller than that with water. The mean pe ak serum concentration was decreased to 60% after oral administration of norfloxacin with milk (P < 0.01). The apparent volume of distributi on at central compartment (V-c/f) value of norfloxacin was significant ly (P < 0.05) increased with milk. Milk exhibits a clinically signific ant effect on norfloxacin absorption.