ENANTIOSELECTIVE SEPARATIONS BY CAPILLARY GC ON DERIVATIZED CYCLODEXTRINS .1. SEPARATION OF SOME RACEMIC 2,2-DIALKYL-4-ALKOXYCARBONYL-1,3-DIOXOLANE DERIVATIVES ON PERMETHYLATED ALPHA-CYCLODEXTRIN, BETA-CYCLODEXTRIN AND GAMMA-CYCLODEXTRIN

The enantioseparation of some 2,2-dialkyl-4-alkoxycarbonyl-1,3-di-oxol ane derivatives, which are important intermediates in the total synthe sis of a number of biologically active compounds, was studied by means of capillary gas chromatography (CGC). The chromatographic results, o btained on columns coated with permethylated alpha-, beta- and gamma-c yclodextrin respectively, are reported. Out of sixteen compounds, thir teen could be separated with a resolution superior to 1,2. One racemat e could not be separated on any of the columns. Considerations concern ing the separation mechanism are proposed.