HUMAN TUMOR-NECROSIS-FACTOR-ALPHA INFLUENCES RAINBOW-TROUT ONCORHYNCHUS-MYKISS LEUKOCYTE RESPONSES

Citation
Lj. Hardie et al., HUMAN TUMOR-NECROSIS-FACTOR-ALPHA INFLUENCES RAINBOW-TROUT ONCORHYNCHUS-MYKISS LEUKOCYTE RESPONSES, Veterinary immunology and immunopathology, 40(1), 1994, pp. 73-84
Citations number
35
Categorie Soggetti
Immunology,"Veterinary Sciences
ISSN journal
01652427
Volume
40
Issue
1
Year of publication
1994
Pages
73 - 84
Database
ISI
SICI code
0165-2427(1994)40:1<73:HTIRO>2.0.ZU;2-1
Abstract
Human recombinant tumor necrosis factor alpha (rTNFalpha) and rainbow trout macrophage activating factor (postulated gamma-interferon (gamma -IFN) analogue) synergised to elevate the respiratory burst activity o f trout macrophages. This elevated response may parallel phenomena des cribed in mammals where TNFalpha and gamma-IFN commonly synergise. Hum an rTNFalpha also synergised with mitogenic stimuli to heighten prolif eration responses of trout head kidney leucocytes. These data are indi cative of a conserved TNFalpha receptor on trout leucocytes (and possi bly the TNFalpha molecule itself) and support the notion of an interac tive cytokine network regulating immune responses in fish.