SYNTHESIS OF A NEW HYDROXYETHYLENE DIPEPTIDE ISOSTERE PHE PSI [CH2CH(OH)]PHE AS HIV-1 PROTEASE INHIBITOR

Authors
CHEN HG SAWYER TK WUTS PGM
Citation
Hg. Chen et al., SYNTHESIS OF A NEW HYDROXYETHYLENE DIPEPTIDE ISOSTERE PHE PSI [CH2CH(OH)]PHE AS HIV-1 PROTEASE INHIBITOR, Zhongguo yaoli xuebao, 15(1), 1994, pp. 33-35
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Zhongguo yaoli xuebao → ACNP
ISSN journal
02539756
Volume
15
Issue
1
Year of publication
1994
Pages
33 - 35
Database
ISI
SICI code
0253-9756(1994)15:1<33:SOANHD>2.0.ZU;2-E
Abstract
A new type of pseudodipeptide isostere exampled by PhePSI[CH2CH(OH)]Ph e was synthesized from phenylalanine. The HIV protease inhibitory acti vity (IC50) of Noa-His-PhePSI[CH2CH(OH)]Phe-Ile-Amp was 0.8 pmol . L-1 .