Hg. Chen et al., SYNTHESIS OF A NEW HYDROXYETHYLENE DIPEPTIDE ISOSTERE PHE PSI [CH2CH(OH)]PHE AS HIV-1 PROTEASE INHIBITOR, Zhongguo yaoli xuebao, 15(1), 1994, pp. 33-35
A new type of pseudodipeptide isostere exampled by PhePSI[CH2CH(OH)]Ph
e was synthesized from phenylalanine. The HIV protease inhibitory acti
vity (IC50) of Noa-His-PhePSI[CH2CH(OH)]Phe-Ile-Amp was 0.8 pmol . L-1
.