SODIUM FERULATE ALLEVIATED PARACETAMOL-IN DUCED LIVER TOXICITY IN MICE

Sodium ferulate (SF) is one of the effective components of Angelica si nensis Diels. Pretreatment with SF (100 mg-kg-1 ig, qd X 10 d) inhibit ed the activity of serum alanine aminotransferase, prevented the deple tion of liver glycogen and glutathione, increased the liver homogenate and microsomal glutathione S-transferase activities, and reduced the malondialdehyde content, the membrane fluidity of liver microsome and the mitochondria in paracetamol (130 mg . kg-1, ip)-induced liver toxi city in mice. These results demonstrated the hepato-protective action of SF in mice.