DISTRIBUTION OF I-131 CYTOTOXIN 14 FROM N AJA-NAJA-ATRA VENOM IN RATS

Authors
GUO MP WANG QC LIU GF
Citation
Mp. Guo et al., DISTRIBUTION OF I-131 CYTOTOXIN 14 FROM N AJA-NAJA-ATRA VENOM IN RATS, Zhongguo yaoli xuebao, 15(1), 1994, pp. 90-92
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Zhongguo yaoli xuebao → ACNP
ISSN journal
02539756
Volume
15
Issue
1
Year of publication
1994
Pages
90 - 92
Database
ISI
SICI code
0253-9756(1994)15:1<90:DOIC1F>2.0.ZU;2-C
Abstract
Cytotoxin 14 (CT14) from Naja naja atra venom was labelled with I-131 by chloramine-T method and its tissue distribution was studied in rats . The highest concentration of the cytotoxin was found in kidney, 5979 dpm per mg weight, 14 times more than that of the control animals, at 0.5 h after iv injection and high concentrations were found in, liver , spleen, pancreas, and adrenal. CT14 was also found in brain at 2 h a fter injection, 50 dpm per mg weight, 3 times more than that of the co ntrol.