The inhibitory effect of interleukin (IL)-1 on thyroid cell functions,
including cAMP and thyroglobulin production, is well documented. Rece
ntly, IL-1 was shown to enhance the production of IL-6 from thyrocytes
, and IL-1 receptors were demonstrated on normal thyroid cells. The or
igin of IL-1 could be from infiltrating monocytes/-macrophages, endoth
elial cells as well as from the thyrocytes themselves. Thus, IL-1 acti
vated thyrocyte may participate directly in the immunological process
by reacting to and producing immunoinflammatory cytokines.