The Cytobrush Plus cell collector (cytobrush) was compared with the wo
oden tongue depressor during oral exfoliative cytology. The degree of
patient discomfort, the convenience to the clinician, and the quantity
and distribution of epithelial cells collected were evaluated. Two-fa
ctor analysis of variance and parametric and nonparametric analyses we
re performed. Because of the favorable findings revealed in this study
, we recommend that the cytobrush be considered for use when obtaining
diagnostic cytologic smears from the oral mucosa.