DISSOCIATE ARACHIDONIC-ACID RELEASE FROM EICOSANOID SYNTHESIS IN RAT PERITONEAL-MACROPHAGES IS POSSIBLE USING CONCOMITANTLY EICOSAPENTANOICACID AS A PHOSPHOLIPID ANALOG

Authors
BOURASS J BOUCROT P LETOURNEUX Y GANDEMER G PETIT JY
Citation
J. Bourass et al., DISSOCIATE ARACHIDONIC-ACID RELEASE FROM EICOSANOID SYNTHESIS IN RAT PERITONEAL-MACROPHAGES IS POSSIBLE USING CONCOMITANTLY EICOSAPENTANOICACID AS A PHOSPHOLIPID ANALOG, Pharmacological research, 33(6), 1996, pp. 343-347
Citations number
31
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacological research → ACNP
ISSN journal
10436618
Volume
33
Issue
6
Year of publication
1996
Pages
343 - 347
Database
ISI
SICI code
1043-6618(1996)33:6<343:DARFES>2.0.ZU;2-8
Abstract
Activated macrophages exposed to the association of eicosapentanoic ac id 20:5 n-3 and a synthetic non hydrolysable phospholipid analogue mai ntained a discrete synthesis of active eicosanoids. 20:4 n-6 splited f rom the internalized 20:4-GPC was accumulated in cells and extracellul ar fluids. This combination thus represents a novel approach to reduce the 20:4 n-6 cascade. (C) 1996 The Italian Pharmacological Society