CHEMISTRY OF INDOLES CARRYING A BASIC FUNCTION .3. SYNTHESIS OF SPIRO[CYCLOPROPANE-1,3'[3H]INDOL]-2'(1'H)-ONES WITH ANTIHYPOXIC EFFECTS

Authors
MOLDVAI I GACSBAITZ E BALAZS M INCZE M SZANTAY C
Citation
I. Moldvai et al., CHEMISTRY OF INDOLES CARRYING A BASIC FUNCTION .3. SYNTHESIS OF SPIRO[CYCLOPROPANE-1,3'[3H]INDOL]-2'(1'H)-ONES WITH ANTIHYPOXIC EFFECTS, Archiv der pharmazie, 329(12), 1996, pp. 541-549
Citations number
11
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
329
Issue
12
Year of publication
1996
Pages
541 - 549
Database
ISI
SICI code
0365-6233(1996)329:12<541:COICAB>2.0.ZU;2-0
Abstract
Hydroxyindolones (1-6, 15-16) were transformed into isatinylidenes (7, 9-13, 17-19) by dehydration with 4-toluenesulfonic acid. The dimer-ty pe compounds (14, 20) were also isolated in few cases. The obtained is atinylidenes were transformed into 3-spiro-cyclopropane-oxindoles (21- 32) with dimethyloxosulfonium methylide. Compound 22 shows protective effects against hypobaric hypoxia and triethyltin induced brain edema.