NONRANDOM SECONDARY CHROMOSOME-ABERRATIONS IN LIPOSARCOMAS WITH T(12,16)

Ten liposarcomas were analyzed cytogenetically after short-term cultur ing. Eight tumors had a t(12;16) (q13;p11) and two tumors had complex translocations involving chromosomes 7, 12, and 16 and 2, 9, 12, 16 an d 20, respectively. Among the secondary aberrations seen in five tumor s, +8 was found in two tumors and i(7)(q10) in four tumors. Trisomy 8 has previously been described as a nonrandom secondary aberration in m yxoid liposarcoma, but i(7q) has only been reported in a single case b efore. All recurrent chromosome aberrations reported in liposarcomas w ith recombination between 12q13 and 16p11 (42 cases) were surveyed and compared with their frequencies in liposarcomas without this recombin ation (33 cases). Trisomy 5 and 8 were found in both tumor groups, whe reas +19, t(3;15)(p23;q15), del(6)(q21), i(7q), and rearrangements of 1p11 and 2q35 were found exclusively in tumors with 12q13 and 16p11 ab errations.